Neuropeptide y drug development neuropeptide y npy belongs to a family of peptides which also includes peptide yy and pancreatic polypeptide these peptides share considerable amino acid homology and act on a common family of receptors since the discovery of npy in 1982 two observations have generated interest in this peptide. Neuropeptide y npy is one of the most abundant peptides found in mammalian brain it is found that at least four classes of npy receptors are present in various tissues designated y1 y2 and y3 with the three cloned receptors referred to the y4 or pp1 y5 and y6 receptor types npy peptide yy pyy are highly potent while the c terminal fragments of npy and pyy and the pps are active only in the micromolar range at the y1 receptor type membrane binding assays revealed that the y1 . Neuropeptide y and drug development previous article 2 adrenergic receptors structure function and therapeutic implications abstract edited by l grundemar and s r bloomacademic press 1997 gbp5000 209 pagesisbn 0 12 304990 3 keywords neuropeptide y drug development to read this article in full you will need to make a payment purchase one time access read it now purchase . Neuropeptide y npy is a ubiquitous and important messenger in the nervous system with a wide range of physiological roles it is involved in the body energy balance and is one of the most potent stimuli of food intake known npy also acts to regulate central and peripheral autonomic functions this book written by academic and industrial